diff --git a/src/compiler/checker.ts b/src/compiler/checker.ts
index 3a888dc5277..93f559c1faa 100644
--- a/src/compiler/checker.ts
+++ b/src/compiler/checker.ts
@@ -16124,7 +16124,7 @@ export function createTypeChecker(host: TypeCheckerHost): TypeChecker {
     }
 
     function removeStringLiteralsMatchedByTemplateLiterals(types: Type[]) {
-        const templates = filter(types, isPatternLiteralType) as TemplateLiteralType[];
+        const templates = filter(types, t => !!(t.flags & TypeFlags.TemplateLiteral) && isPatternLiteralType(t)) as TemplateLiteralType[];
         if (templates.length) {
             let i = types.length;
             while (i > 0) {
diff --git a/tests/baselines/reference/templateLiteralTypes3.errors.txt b/tests/baselines/reference/templateLiteralTypes3.errors.txt
index 5a70a5a5f8d..0757775e413 100644
--- a/tests/baselines/reference/templateLiteralTypes3.errors.txt
+++ b/tests/baselines/reference/templateLiteralTypes3.errors.txt
@@ -217,4 +217,8 @@ tests/cases/conformance/types/literal/templateLiteralTypes3.ts(141,9): error TS2
         spread(`1.${u}.3`, `1.${u}.4`);
         spread(u1, u2);
     }
+    
+    // Repro from #52685
+    
+    type Boom = 'abc' | 'def' | `a${string}` | Lowercase<string>;
     
\ No newline at end of file
diff --git a/tests/baselines/reference/templateLiteralTypes3.js b/tests/baselines/reference/templateLiteralTypes3.js
index f25296c0aef..a644bb56088 100644
--- a/tests/baselines/reference/templateLiteralTypes3.js
+++ b/tests/baselines/reference/templateLiteralTypes3.js
@@ -189,6 +189,10 @@ function ft1<T extends string>(t: T, u: Uppercase<T>, u1: Uppercase<`1.${T}.3`>,
     spread(`1.${u}.3`, `1.${u}.4`);
     spread(u1, u2);
 }
+
+// Repro from #52685
+
+type Boom = 'abc' | 'def' | `a${string}` | Lowercase<string>;
 
 
 //// [templateLiteralTypes3.js]
@@ -356,3 +360,4 @@ type DotString = `${string}.${string}.${string}`;
 declare function noSpread<P extends DotString>(args: P[]): P;
 declare function spread<P extends DotString>(...args: P[]): P;
 declare function ft1<T extends string>(t: T, u: Uppercase<T>, u1: Uppercase<`1.${T}.3`>, u2: Uppercase<`1.${T}.4`>): void;
+type Boom = 'abc' | 'def' | `a${string}` | Lowercase<string>;
diff --git a/tests/baselines/reference/templateLiteralTypes3.symbols b/tests/baselines/reference/templateLiteralTypes3.symbols
index 47f4ee7fe6e..cfb3b01c7a4 100644
--- a/tests/baselines/reference/templateLiteralTypes3.symbols
+++ b/tests/baselines/reference/templateLiteralTypes3.symbols
@@ -580,3 +580,9 @@ function ft1<T extends string>(t: T, u: Uppercase<T>, u1: Uppercase<`1.${T}.3`>,
 >u2 : Symbol(u2, Decl(templateLiteralTypes3.ts, 185, 80))
 }
 
+// Repro from #52685
+
+type Boom = 'abc' | 'def' | `a${string}` | Lowercase<string>;
+>Boom : Symbol(Boom, Decl(templateLiteralTypes3.ts, 189, 1))
+>Lowercase : Symbol(Lowercase, Decl(lib.es5.d.ts, --, --))
+
diff --git a/tests/baselines/reference/templateLiteralTypes3.types b/tests/baselines/reference/templateLiteralTypes3.types
index 3fb7144050b..c2822fa8d27 100644
--- a/tests/baselines/reference/templateLiteralTypes3.types
+++ b/tests/baselines/reference/templateLiteralTypes3.types
@@ -594,3 +594,8 @@ function ft1<T extends string>(t: T, u: Uppercase<T>, u1: Uppercase<`1.${T}.3`>,
 >u2 : `1.${Uppercase<T>}.4`
 }
 
+// Repro from #52685
+
+type Boom = 'abc' | 'def' | `a${string}` | Lowercase<string>;
+>Boom : `a${string}` | Lowercase<string> | "def"
+
diff --git a/tests/cases/conformance/types/literal/templateLiteralTypes3.ts b/tests/cases/conformance/types/literal/templateLiteralTypes3.ts
index 8c47fff8cb2..3103c48201d 100644
--- a/tests/cases/conformance/types/literal/templateLiteralTypes3.ts
+++ b/tests/cases/conformance/types/literal/templateLiteralTypes3.ts
@@ -191,3 +191,7 @@ function ft1<T extends string>(t: T, u: Uppercase<T>, u1: Uppercase<`1.${T}.3`>,
     spread(`1.${u}.3`, `1.${u}.4`);
     spread(u1, u2);
 }
+
+// Repro from #52685
+
+type Boom = 'abc' | 'def' | `a${string}` | Lowercase<string>;