diff --git a/src/compiler/checker.ts b/src/compiler/checker.ts
index 2b8244ca06c..ef107c2bc68 100644
--- a/src/compiler/checker.ts
+++ b/src/compiler/checker.ts
@@ -15845,17 +15845,35 @@ namespace ts {
             });
         }
 
-        function checkNonNullExpression(node: Expression | QualifiedName) {
-            return checkNonNullType(checkExpression(node), node);
+        function checkNonNullExpression(
+            node: Expression | QualifiedName,
+            nullDiagnostic?: DiagnosticMessage,
+            undefinedDiagnostic?: DiagnosticMessage,
+            nullOrUndefinedDiagnostic?: DiagnosticMessage,
+        ) {
+            return checkNonNullType(
+                checkExpression(node),
+                node,
+                nullDiagnostic,
+                undefinedDiagnostic,
+                nullOrUndefinedDiagnostic
+            );
         }
 
-        function checkNonNullType(type: Type, errorNode: Node): Type {
+        function checkNonNullType(
+            type: Type,
+            node: Node,
+            nullDiagnostic?: DiagnosticMessage,
+            undefinedDiagnostic?: DiagnosticMessage,
+            nullOrUndefinedDiagnostic?: DiagnosticMessage
+        ): Type {
             const kind = (strictNullChecks ? getFalsyFlags(type) : type.flags) & TypeFlags.Nullable;
             if (kind) {
-                error(errorNode, kind & TypeFlags.Undefined ? kind & TypeFlags.Null ?
-                    Diagnostics.Object_is_possibly_null_or_undefined :
-                    Diagnostics.Object_is_possibly_undefined :
-                    Diagnostics.Object_is_possibly_null);
+                error(node, kind & TypeFlags.Undefined ? kind & TypeFlags.Null ?
+                    (nullOrUndefinedDiagnostic || Diagnostics.Object_is_possibly_null_or_undefined) :
+                    (undefinedDiagnostic || Diagnostics.Object_is_possibly_undefined) :
+                    (nullDiagnostic || Diagnostics.Object_is_possibly_null)
+                );
                 const t = getNonNullableType(type);
                 return t.flags & (TypeFlags.Nullable | TypeFlags.Never) ? unknownType : t;
             }
@@ -17364,7 +17382,13 @@ namespace ts {
                 return resolveUntypedCall(node);
             }
 
-            const funcType = checkNonNullExpression(node.expression);
+            const funcType = checkNonNullExpression(
+                node.expression,
+                Diagnostics.Cannot_invoke_an_object_which_is_possibly_null,
+                Diagnostics.Cannot_invoke_an_object_which_is_possibly_undefined,
+                Diagnostics.Cannot_invoke_an_object_which_is_possibly_null_or_undefined
+            );
+
             if (funcType === silentNeverType) {
                 return silentNeverSignature;
             }
diff --git a/src/compiler/diagnosticMessages.json b/src/compiler/diagnosticMessages.json
index d4641184f45..4fa32251549 100644
--- a/src/compiler/diagnosticMessages.json
+++ b/src/compiler/diagnosticMessages.json
@@ -2288,7 +2288,18 @@
         "category": "Error",
         "code": 2720
     },
-
+    "Cannot invoke an object which is possibly 'null'.": {
+        "category": "Error",
+        "code": 2721
+    },
+    "Cannot invoke an object which is possibly 'undefined'.": {
+        "category": "Error",
+        "code": 2722
+    },
+    "Cannot invoke an object which is possibly 'null' or 'undefined'.": {
+        "category": "Error",
+        "code": 2723
+    },
     "Import declaration '{0}' is using private name '{1}'.": {
         "category": "Error",
         "code": 4000
diff --git a/tests/baselines/reference/nullableFunctionError.errors.txt b/tests/baselines/reference/nullableFunctionError.errors.txt
new file mode 100644
index 00000000000..074afdaee4f
--- /dev/null
+++ b/tests/baselines/reference/nullableFunctionError.errors.txt
@@ -0,0 +1,17 @@
+tests/cases/compiler/nullableFunctionError.ts(1,1): error TS2721: Cannot invoke an object which is possibly 'null'.
+tests/cases/compiler/nullableFunctionError.ts(2,1): error TS2722: Cannot invoke an object which is possibly 'undefined'.
+tests/cases/compiler/nullableFunctionError.ts(4,1): error TS2723: Cannot invoke an object which is possibly 'null' or 'undefined'.
+
+
+==== tests/cases/compiler/nullableFunctionError.ts (3 errors) ====
+    null();
+    ~~~~
+!!! error TS2721: Cannot invoke an object which is possibly 'null'.
+    undefined();
+    ~~~~~~~~~
+!!! error TS2722: Cannot invoke an object which is possibly 'undefined'.
+    let f: null | undefined;
+    f();
+    ~
+!!! error TS2723: Cannot invoke an object which is possibly 'null' or 'undefined'.
+    
\ No newline at end of file
diff --git a/tests/baselines/reference/nullableFunctionError.js b/tests/baselines/reference/nullableFunctionError.js
new file mode 100644
index 00000000000..a8b1f28c51a
--- /dev/null
+++ b/tests/baselines/reference/nullableFunctionError.js
@@ -0,0 +1,12 @@
+//// [nullableFunctionError.ts]
+null();
+undefined();
+let f: null | undefined;
+f();
+
+
+//// [nullableFunctionError.js]
+null();
+undefined();
+var f;
+f();
diff --git a/tests/baselines/reference/nullableFunctionError.symbols b/tests/baselines/reference/nullableFunctionError.symbols
new file mode 100644
index 00000000000..cb066bdb32d
--- /dev/null
+++ b/tests/baselines/reference/nullableFunctionError.symbols
@@ -0,0 +1,11 @@
+=== tests/cases/compiler/nullableFunctionError.ts ===
+null();
+undefined();
+>undefined : Symbol(undefined)
+
+let f: null | undefined;
+>f : Symbol(f, Decl(nullableFunctionError.ts, 2, 3))
+
+f();
+>f : Symbol(f, Decl(nullableFunctionError.ts, 2, 3))
+
diff --git a/tests/baselines/reference/nullableFunctionError.types b/tests/baselines/reference/nullableFunctionError.types
new file mode 100644
index 00000000000..97697fbb564
--- /dev/null
+++ b/tests/baselines/reference/nullableFunctionError.types
@@ -0,0 +1,17 @@
+=== tests/cases/compiler/nullableFunctionError.ts ===
+null();
+>null() : any
+>null : null
+
+undefined();
+>undefined() : any
+>undefined : undefined
+
+let f: null | undefined;
+>f : null | undefined
+>null : null
+
+f();
+>f() : any
+>f : null | undefined
+
diff --git a/tests/cases/compiler/nullableFunctionError.ts b/tests/cases/compiler/nullableFunctionError.ts
new file mode 100644
index 00000000000..5477d7fa29a
--- /dev/null
+++ b/tests/cases/compiler/nullableFunctionError.ts
@@ -0,0 +1,6 @@
+// @strictNullChecks: true
+
+null();
+undefined();
+let f: null | undefined;
+f();