diff --git a/src/compiler/binder.ts b/src/compiler/binder.ts
index d26da9bcbf0..8ff6712ad30 100644
--- a/src/compiler/binder.ts
+++ b/src/compiler/binder.ts
@@ -2947,6 +2947,7 @@ namespace ts {
                 case SyntaxKind.MethodDeclaration:
                 case SyntaxKind.GetAccessor:
                 case SyntaxKind.SetAccessor:
+                case SyntaxKind.ClassStaticBlockDeclaration:
                     // this.foo assignment in a JavaScript class
                     // Bind this property to the containing class
                     const containingClass = thisContainer.parent;
diff --git a/tests/baselines/reference/javascriptThisAssignmentInStaticBlock.errors.txt b/tests/baselines/reference/javascriptThisAssignmentInStaticBlock.errors.txt
new file mode 100644
index 00000000000..a4729d56ef5
--- /dev/null
+++ b/tests/baselines/reference/javascriptThisAssignmentInStaticBlock.errors.txt
@@ -0,0 +1,30 @@
+/src/a.js(10,7): error TS2417: Class static side 'typeof ElementsArray' incorrectly extends base class static side '{ isArray(arg: any): arg is any[]; readonly prototype: any[]; }'.
+  Types of property 'isArray' are incompatible.
+    Type '(arg: any) => boolean' is not assignable to type '(arg: any) => arg is any[]'.
+      Signature '(arg: any): boolean' must be a type predicate.
+
+
+==== /src/a.js (1 errors) ====
+    class Thing {
+        static {
+            this.doSomething = () => {};
+        }
+    }
+    
+    Thing.doSomething();
+    
+    // GH#46468
+    class ElementsArray extends Array {
+          ~~~~~~~~~~~~~
+!!! error TS2417: Class static side 'typeof ElementsArray' incorrectly extends base class static side '{ isArray(arg: any): arg is any[]; readonly prototype: any[]; }'.
+!!! error TS2417:   Types of property 'isArray' are incompatible.
+!!! error TS2417:     Type '(arg: any) => boolean' is not assignable to type '(arg: any) => arg is any[]'.
+!!! error TS2417:       Signature '(arg: any): boolean' must be a type predicate.
+        static {
+            const superisArray = super.isArray;
+            const customIsArray = (arg)=> superisArray(arg);
+            this.isArray = customIsArray;
+        }
+    }
+    
+    ElementsArray.isArray(new ElementsArray());
\ No newline at end of file
diff --git a/tests/baselines/reference/javascriptThisAssignmentInStaticBlock.js b/tests/baselines/reference/javascriptThisAssignmentInStaticBlock.js
new file mode 100644
index 00000000000..5d25a1a9e49
--- /dev/null
+++ b/tests/baselines/reference/javascriptThisAssignmentInStaticBlock.js
@@ -0,0 +1,73 @@
+//// [a.js]
+class Thing {
+    static {
+        this.doSomething = () => {};
+    }
+}
+
+Thing.doSomething();
+
+// GH#46468
+class ElementsArray extends Array {
+    static {
+        const superisArray = super.isArray;
+        const customIsArray = (arg)=> superisArray(arg);
+        this.isArray = customIsArray;
+    }
+}
+
+ElementsArray.isArray(new ElementsArray());
+
+//// [a.js]
+var __extends = (this && this.__extends) || (function () {
+    var extendStatics = function (d, b) {
+        extendStatics = Object.setPrototypeOf ||
+            ({ __proto__: [] } instanceof Array && function (d, b) { d.__proto__ = b; }) ||
+            function (d, b) { for (var p in b) if (Object.prototype.hasOwnProperty.call(b, p)) d[p] = b[p]; };
+        return extendStatics(d, b);
+    };
+    return function (d, b) {
+        if (typeof b !== "function" && b !== null)
+            throw new TypeError("Class extends value " + String(b) + " is not a constructor or null");
+        extendStatics(d, b);
+        function __() { this.constructor = d; }
+        d.prototype = b === null ? Object.create(b) : (__.prototype = b.prototype, new __());
+    };
+})();
+var _a, _b;
+var _this = this;
+var Thing = /** @class */ (function () {
+    function Thing() {
+    }
+    return Thing;
+}());
+_a = Thing;
+(function () {
+    _a.doSomething = function () { };
+})();
+Thing.doSomething();
+// GH#46468
+var ElementsArray = /** @class */ (function (_super) {
+    __extends(ElementsArray, _super);
+    function ElementsArray() {
+        return _super !== null && _super.apply(this, arguments) || this;
+    }
+    return ElementsArray;
+}(Array));
+_b = ElementsArray;
+(function () {
+    var superisArray = _super.isArray;
+    var customIsArray = function (arg) { return superisArray(arg); };
+    _b.isArray = customIsArray;
+})();
+ElementsArray.isArray(new ElementsArray());
+
+
+//// [a.d.ts]
+declare class Thing {
+}
+declare class ElementsArray extends Array<any> {
+    constructor(arrayLength?: number);
+    constructor(arrayLength: number);
+    constructor(...items: any[]);
+}
diff --git a/tests/baselines/reference/javascriptThisAssignmentInStaticBlock.symbols b/tests/baselines/reference/javascriptThisAssignmentInStaticBlock.symbols
new file mode 100644
index 00000000000..51d648a9ed7
--- /dev/null
+++ b/tests/baselines/reference/javascriptThisAssignmentInStaticBlock.symbols
@@ -0,0 +1,49 @@
+=== /src/a.js ===
+class Thing {
+>Thing : Symbol(Thing, Decl(a.js, 0, 0))
+
+    static {
+        this.doSomething = () => {};
+>this.doSomething : Symbol(Thing.doSomething, Decl(a.js, 1, 12))
+>this : Symbol(Thing, Decl(a.js, 0, 0))
+>doSomething : Symbol(Thing.doSomething, Decl(a.js, 1, 12))
+    }
+}
+
+Thing.doSomething();
+>Thing.doSomething : Symbol(Thing.doSomething, Decl(a.js, 1, 12))
+>Thing : Symbol(Thing, Decl(a.js, 0, 0))
+>doSomething : Symbol(Thing.doSomething, Decl(a.js, 1, 12))
+
+// GH#46468
+class ElementsArray extends Array {
+>ElementsArray : Symbol(ElementsArray, Decl(a.js, 6, 20))
+>Array : Symbol(Array, Decl(lib.es5.d.ts, --, --), Decl(lib.es5.d.ts, --, --))
+
+    static {
+        const superisArray = super.isArray;
+>superisArray : Symbol(superisArray, Decl(a.js, 11, 13))
+>super.isArray : Symbol(ArrayConstructor.isArray, Decl(lib.es5.d.ts, --, --))
+>super : Symbol(ArrayConstructor, Decl(lib.es5.d.ts, --, --))
+>isArray : Symbol(ArrayConstructor.isArray, Decl(lib.es5.d.ts, --, --))
+
+        const customIsArray = (arg)=> superisArray(arg);
+>customIsArray : Symbol(customIsArray, Decl(a.js, 12, 13))
+>arg : Symbol(arg, Decl(a.js, 12, 31))
+>superisArray : Symbol(superisArray, Decl(a.js, 11, 13))
+>arg : Symbol(arg, Decl(a.js, 12, 31))
+
+        this.isArray = customIsArray;
+>this.isArray : Symbol(ElementsArray.isArray, Decl(a.js, 12, 56))
+>this : Symbol(ElementsArray, Decl(a.js, 6, 20))
+>isArray : Symbol(ElementsArray.isArray, Decl(a.js, 12, 56))
+>customIsArray : Symbol(customIsArray, Decl(a.js, 12, 13))
+    }
+}
+
+ElementsArray.isArray(new ElementsArray());
+>ElementsArray.isArray : Symbol(ElementsArray.isArray, Decl(a.js, 12, 56))
+>ElementsArray : Symbol(ElementsArray, Decl(a.js, 6, 20))
+>isArray : Symbol(ElementsArray.isArray, Decl(a.js, 12, 56))
+>ElementsArray : Symbol(ElementsArray, Decl(a.js, 6, 20))
+
diff --git a/tests/baselines/reference/javascriptThisAssignmentInStaticBlock.types b/tests/baselines/reference/javascriptThisAssignmentInStaticBlock.types
new file mode 100644
index 00000000000..bbb41f4ea47
--- /dev/null
+++ b/tests/baselines/reference/javascriptThisAssignmentInStaticBlock.types
@@ -0,0 +1,57 @@
+=== /src/a.js ===
+class Thing {
+>Thing : Thing
+
+    static {
+        this.doSomething = () => {};
+>this.doSomething = () => {} : () => void
+>this.doSomething : () => void
+>this : typeof Thing
+>doSomething : () => void
+>() => {} : () => void
+    }
+}
+
+Thing.doSomething();
+>Thing.doSomething() : void
+>Thing.doSomething : () => void
+>Thing : typeof Thing
+>doSomething : () => void
+
+// GH#46468
+class ElementsArray extends Array {
+>ElementsArray : ElementsArray
+>Array : any[]
+
+    static {
+        const superisArray = super.isArray;
+>superisArray : (arg: any) => arg is any[]
+>super.isArray : (arg: any) => arg is any[]
+>super : ArrayConstructor
+>isArray : (arg: any) => arg is any[]
+
+        const customIsArray = (arg)=> superisArray(arg);
+>customIsArray : (arg: any) => boolean
+>(arg)=> superisArray(arg) : (arg: any) => boolean
+>arg : any
+>superisArray(arg) : boolean
+>superisArray : (arg: any) => arg is any[]
+>arg : any
+
+        this.isArray = customIsArray;
+>this.isArray = customIsArray : (arg: any) => boolean
+>this.isArray : (arg: any) => boolean
+>this : typeof ElementsArray
+>isArray : (arg: any) => boolean
+>customIsArray : (arg: any) => boolean
+    }
+}
+
+ElementsArray.isArray(new ElementsArray());
+>ElementsArray.isArray(new ElementsArray()) : boolean
+>ElementsArray.isArray : (arg: any) => boolean
+>ElementsArray : typeof ElementsArray
+>isArray : (arg: any) => boolean
+>new ElementsArray() : ElementsArray
+>ElementsArray : typeof ElementsArray
+
diff --git a/tests/cases/compiler/javascriptThisAssignmentInStaticBlock.ts b/tests/cases/compiler/javascriptThisAssignmentInStaticBlock.ts
new file mode 100644
index 00000000000..f86508dc986
--- /dev/null
+++ b/tests/cases/compiler/javascriptThisAssignmentInStaticBlock.ts
@@ -0,0 +1,24 @@
+// @allowJs: true
+// @checkJs: true
+// @declaration: true
+// @outDir: /out/
+// @filename: /src/a.js
+
+class Thing {
+    static {
+        this.doSomething = () => {};
+    }
+}
+
+Thing.doSomething();
+
+// GH#46468
+class ElementsArray extends Array {
+    static {
+        const superisArray = super.isArray;
+        const customIsArray = (arg)=> superisArray(arg);
+        this.isArray = customIsArray;
+    }
+}
+
+ElementsArray.isArray(new ElementsArray());
\ No newline at end of file