diff --git a/src/compiler/checker.ts b/src/compiler/checker.ts
index 05d42573b66..3d4917c2389 100644
--- a/src/compiler/checker.ts
+++ b/src/compiler/checker.ts
@@ -23348,6 +23348,15 @@ m2: ${(this.mapper2 as unknown as DebugTypeMapper).__debugToString().split("\n")
                         const key = getFlowCacheKey((node as AccessExpression).expression, declaredType, initialType, flowContainer);
                         return key && key + "." + propName;
                     }
+                    break;
+                case SyntaxKind.ObjectBindingPattern:
+                case SyntaxKind.ArrayBindingPattern:
+                case SyntaxKind.FunctionDeclaration:
+                case SyntaxKind.FunctionExpression:
+                case SyntaxKind.ArrowFunction:
+                case SyntaxKind.MethodDeclaration:
+                    // Handle pseudo-references originating in getNarrowedTypeOfSymbol.
+                    return `${getNodeId(node)}#${getTypeId(declaredType)}`;
             }
             return undefined;
         }
diff --git a/tests/baselines/reference/dependentDestructuredVariables.errors.txt b/tests/baselines/reference/dependentDestructuredVariables.errors.txt
index fbddf80744c..e3704b567ac 100644
--- a/tests/baselines/reference/dependentDestructuredVariables.errors.txt
+++ b/tests/baselines/reference/dependentDestructuredVariables.errors.txt
@@ -331,4 +331,47 @@ tests/cases/conformance/controlFlow/dependentDestructuredVariables.ts(314,5): er
         test8 = value1.test8,
         test9 = value1.test9
     }) {}
+    
+    // Repro from #49772
+    
+    function fa1(x: [true, number] | [false, string]) {
+        const [guard, value] = x;
+        if (guard) {
+            for (;;) {
+                value;  // number
+            }
+        }
+        else {
+            while (!!true) {
+                value;  // string
+            }
+        }
+    }
+    
+    function fa2(x: { guard: true, value: number } | { guard: false, value: string }) {
+        const { guard, value } = x;
+        if (guard) {
+            for (;;) {
+                value;  // number
+            }
+        }
+        else {
+            while (!!true) {
+                value;  // string
+            }
+        }
+    }
+    
+    const fa3: (...args: [true, number] | [false, string]) => void = (guard, value) => {
+        if (guard) {
+            for (;;) {
+                value;  // number
+            }
+        }
+        else {
+            while (!!true) {
+                value;  // string
+            }
+        }
+    }
     
\ No newline at end of file
diff --git a/tests/baselines/reference/dependentDestructuredVariables.js b/tests/baselines/reference/dependentDestructuredVariables.js
index eab12767faf..6971c1ad1d2 100644
--- a/tests/baselines/reference/dependentDestructuredVariables.js
+++ b/tests/baselines/reference/dependentDestructuredVariables.js
@@ -323,6 +323,49 @@ function foo({
     test8 = value1.test8,
     test9 = value1.test9
 }) {}
+
+// Repro from #49772
+
+function fa1(x: [true, number] | [false, string]) {
+    const [guard, value] = x;
+    if (guard) {
+        for (;;) {
+            value;  // number
+        }
+    }
+    else {
+        while (!!true) {
+            value;  // string
+        }
+    }
+}
+
+function fa2(x: { guard: true, value: number } | { guard: false, value: string }) {
+    const { guard, value } = x;
+    if (guard) {
+        for (;;) {
+            value;  // number
+        }
+    }
+    else {
+        while (!!true) {
+            value;  // string
+        }
+    }
+}
+
+const fa3: (...args: [true, number] | [false, string]) => void = (guard, value) => {
+    if (guard) {
+        for (;;) {
+            value;  // number
+        }
+    }
+    else {
+        while (!!true) {
+            value;  // string
+        }
+    }
+}
 
 
 //// [dependentDestructuredVariables.js]
@@ -567,6 +610,45 @@ const f60 = (kind, payload) => {
 };
 // Repro from #48902
 function foo({ value1, test1 = value1.test1, test2 = value1.test2, test3 = value1.test3, test4 = value1.test4, test5 = value1.test5, test6 = value1.test6, test7 = value1.test7, test8 = value1.test8, test9 = value1.test9 }) { }
+// Repro from #49772
+function fa1(x) {
+    const [guard, value] = x;
+    if (guard) {
+        for (;;) {
+            value; // number
+        }
+    }
+    else {
+        while (!!true) {
+            value; // string
+        }
+    }
+}
+function fa2(x) {
+    const { guard, value } = x;
+    if (guard) {
+        for (;;) {
+            value; // number
+        }
+    }
+    else {
+        while (!!true) {
+            value; // string
+        }
+    }
+}
+const fa3 = (guard, value) => {
+    if (guard) {
+        for (;;) {
+            value; // number
+        }
+    }
+    else {
+        while (!!true) {
+            value; // string
+        }
+    }
+};
 
 
 //// [dependentDestructuredVariables.d.ts]
@@ -696,3 +778,12 @@ declare function foo({ value1, test1, test2, test3, test4, test5, test6, test7,
     test8?: any;
     test9?: any;
 }): void;
+declare function fa1(x: [true, number] | [false, string]): void;
+declare function fa2(x: {
+    guard: true;
+    value: number;
+} | {
+    guard: false;
+    value: string;
+}): void;
+declare const fa3: (...args: [true, number] | [false, string]) => void;
diff --git a/tests/baselines/reference/dependentDestructuredVariables.symbols b/tests/baselines/reference/dependentDestructuredVariables.symbols
index ccaaaa72fe9..6fed5c24708 100644
--- a/tests/baselines/reference/dependentDestructuredVariables.symbols
+++ b/tests/baselines/reference/dependentDestructuredVariables.symbols
@@ -830,3 +830,81 @@ function foo({
 
 }) {}
 
+// Repro from #49772
+
+function fa1(x: [true, number] | [false, string]) {
+>fa1 : Symbol(fa1, Decl(dependentDestructuredVariables.ts, 323, 5))
+>x : Symbol(x, Decl(dependentDestructuredVariables.ts, 327, 13))
+
+    const [guard, value] = x;
+>guard : Symbol(guard, Decl(dependentDestructuredVariables.ts, 328, 11))
+>value : Symbol(value, Decl(dependentDestructuredVariables.ts, 328, 17))
+>x : Symbol(x, Decl(dependentDestructuredVariables.ts, 327, 13))
+
+    if (guard) {
+>guard : Symbol(guard, Decl(dependentDestructuredVariables.ts, 328, 11))
+
+        for (;;) {
+            value;  // number
+>value : Symbol(value, Decl(dependentDestructuredVariables.ts, 328, 17))
+        }
+    }
+    else {
+        while (!!true) {
+            value;  // string
+>value : Symbol(value, Decl(dependentDestructuredVariables.ts, 328, 17))
+        }
+    }
+}
+
+function fa2(x: { guard: true, value: number } | { guard: false, value: string }) {
+>fa2 : Symbol(fa2, Decl(dependentDestructuredVariables.ts, 339, 1))
+>x : Symbol(x, Decl(dependentDestructuredVariables.ts, 341, 13))
+>guard : Symbol(guard, Decl(dependentDestructuredVariables.ts, 341, 17))
+>value : Symbol(value, Decl(dependentDestructuredVariables.ts, 341, 30))
+>guard : Symbol(guard, Decl(dependentDestructuredVariables.ts, 341, 50))
+>value : Symbol(value, Decl(dependentDestructuredVariables.ts, 341, 64))
+
+    const { guard, value } = x;
+>guard : Symbol(guard, Decl(dependentDestructuredVariables.ts, 342, 11))
+>value : Symbol(value, Decl(dependentDestructuredVariables.ts, 342, 18))
+>x : Symbol(x, Decl(dependentDestructuredVariables.ts, 341, 13))
+
+    if (guard) {
+>guard : Symbol(guard, Decl(dependentDestructuredVariables.ts, 342, 11))
+
+        for (;;) {
+            value;  // number
+>value : Symbol(value, Decl(dependentDestructuredVariables.ts, 342, 18))
+        }
+    }
+    else {
+        while (!!true) {
+            value;  // string
+>value : Symbol(value, Decl(dependentDestructuredVariables.ts, 342, 18))
+        }
+    }
+}
+
+const fa3: (...args: [true, number] | [false, string]) => void = (guard, value) => {
+>fa3 : Symbol(fa3, Decl(dependentDestructuredVariables.ts, 355, 5))
+>args : Symbol(args, Decl(dependentDestructuredVariables.ts, 355, 12))
+>guard : Symbol(guard, Decl(dependentDestructuredVariables.ts, 355, 66))
+>value : Symbol(value, Decl(dependentDestructuredVariables.ts, 355, 72))
+
+    if (guard) {
+>guard : Symbol(guard, Decl(dependentDestructuredVariables.ts, 355, 66))
+
+        for (;;) {
+            value;  // number
+>value : Symbol(value, Decl(dependentDestructuredVariables.ts, 355, 72))
+        }
+    }
+    else {
+        while (!!true) {
+            value;  // string
+>value : Symbol(value, Decl(dependentDestructuredVariables.ts, 355, 72))
+        }
+    }
+}
+
diff --git a/tests/baselines/reference/dependentDestructuredVariables.types b/tests/baselines/reference/dependentDestructuredVariables.types
index f3f90242313..01de281b3d9 100644
--- a/tests/baselines/reference/dependentDestructuredVariables.types
+++ b/tests/baselines/reference/dependentDestructuredVariables.types
@@ -955,3 +955,100 @@ function foo({
 
 }) {}
 
+// Repro from #49772
+
+function fa1(x: [true, number] | [false, string]) {
+>fa1 : (x: [true, number] | [false, string]) => void
+>x : [true, number] | [false, string]
+>true : true
+>false : false
+
+    const [guard, value] = x;
+>guard : boolean
+>value : string | number
+>x : [true, number] | [false, string]
+
+    if (guard) {
+>guard : boolean
+
+        for (;;) {
+            value;  // number
+>value : number
+        }
+    }
+    else {
+        while (!!true) {
+>!!true : true
+>!true : false
+>true : true
+
+            value;  // string
+>value : string
+        }
+    }
+}
+
+function fa2(x: { guard: true, value: number } | { guard: false, value: string }) {
+>fa2 : (x: {    guard: true;    value: number;} | {    guard: false;    value: string;}) => void
+>x : { guard: true; value: number; } | { guard: false; value: string; }
+>guard : true
+>true : true
+>value : number
+>guard : false
+>false : false
+>value : string
+
+    const { guard, value } = x;
+>guard : boolean
+>value : string | number
+>x : { guard: true; value: number; } | { guard: false; value: string; }
+
+    if (guard) {
+>guard : boolean
+
+        for (;;) {
+            value;  // number
+>value : number
+        }
+    }
+    else {
+        while (!!true) {
+>!!true : true
+>!true : false
+>true : true
+
+            value;  // string
+>value : string
+        }
+    }
+}
+
+const fa3: (...args: [true, number] | [false, string]) => void = (guard, value) => {
+>fa3 : (...args: [true, number] | [false, string]) => void
+>args : [true, number] | [false, string]
+>true : true
+>false : false
+>(guard, value) => {    if (guard) {        for (;;) {            value;  // number        }    }    else {        while (!!true) {            value;  // string        }    }} : (guard: boolean, value: string | number) => void
+>guard : boolean
+>value : string | number
+
+    if (guard) {
+>guard : boolean
+
+        for (;;) {
+            value;  // number
+>value : number
+        }
+    }
+    else {
+        while (!!true) {
+>!!true : true
+>!true : false
+>true : true
+
+            value;  // string
+>value : string
+        }
+    }
+}
+
diff --git a/tests/cases/conformance/controlFlow/dependentDestructuredVariables.ts b/tests/cases/conformance/controlFlow/dependentDestructuredVariables.ts
index ae11c010fad..c25f3adf08b 100644
--- a/tests/cases/conformance/controlFlow/dependentDestructuredVariables.ts
+++ b/tests/cases/conformance/controlFlow/dependentDestructuredVariables.ts
@@ -327,3 +327,46 @@ function foo({
     test8 = value1.test8,
     test9 = value1.test9
 }) {}
+
+// Repro from #49772
+
+function fa1(x: [true, number] | [false, string]) {
+    const [guard, value] = x;
+    if (guard) {
+        for (;;) {
+            value;  // number
+        }
+    }
+    else {
+        while (!!true) {
+            value;  // string
+        }
+    }
+}
+
+function fa2(x: { guard: true, value: number } | { guard: false, value: string }) {
+    const { guard, value } = x;
+    if (guard) {
+        for (;;) {
+            value;  // number
+        }
+    }
+    else {
+        while (!!true) {
+            value;  // string
+        }
+    }
+}
+
+const fa3: (...args: [true, number] | [false, string]) => void = (guard, value) => {
+    if (guard) {
+        for (;;) {
+            value;  // number
+        }
+    }
+    else {
+        while (!!true) {
+            value;  // string
+        }
+    }
+}